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Rajagopal V Sekhar Selected Research

Glycine (Aminoacetic Acid)

3/2022GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage.
1/2022GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study.
12/2021Severe Glutathione Deficiency, Oxidative Stress and Oxidant Damage in Adults Hospitalized with COVID-19: Implications for GlyNAC (Glycine and N-Acetylcysteine) Supplementation.
12/2021GlyNAC Supplementation Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Aging Hallmarks, Metabolic Defects, Muscle Strength, Cognitive Decline, and Body Composition: Implications for Healthy Aging.
1/2021Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: Results of a pilot clinical trial.
1/2021Supplementing glycine and N-acetylcysteine (GlyNAC) rapidly improves health-related quality of life and lowers perception of fatigue in patients with HIV.
9/2020Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Endothelial Dysfunction, Insulin Resistance, Genotoxicity, Strength, and Cognition: Results of an Open-Label Clinical Trial.
10/2018Improved Cardiovascular Function in Old Mice After N-Acetyl Cysteine and Glycine Supplemented Diet: Inflammation and Mitochondrial Factors.
9/2015Increasing glutathione concentrations with cysteine and glycine supplementation lowers inflammation in HIV patients.
1/2014Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients.
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Rajagopal V Sekhar Research Topics

Disease

13Insulin Resistance
01/2022 - 05/2004
6Mitochondrial Diseases (Mitochondrial Disease)
03/2022 - 06/2013
6Inflammation (Inflammations)
12/2021 - 05/2004
5Lipodystrophy
04/2013 - 02/2004
5Hypertriglyceridemia
10/2012 - 08/2002
5Dyslipidemias (Dyslipidemia)
07/2011 - 02/2004
4HIV-Associated Lipodystrophy Syndrome
10/2012 - 08/2002
2Type 2 Diabetes Mellitus (MODY)
01/2022 - 01/2011
2Body Weight (Weight, Body)
09/2012 - 08/2005
2Cardiovascular Diseases (Cardiovascular Disease)
05/2004 - 02/2004
1Renal Insufficiency (Renal Failure)
02/2022
1Blindness (Hysterical Blindness)
02/2022
1COVID-19
12/2021
1Infections
12/2021
1Cognitive Dysfunction
12/2021
1Fatigue
01/2021
1Premature Aging
09/2020
1Obesity
04/2013
1Hypoadiponectinemia
07/2011
1Hyperglycemia
01/2011
1Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2006
1Abdominal Obesity
12/2006
1Nelson Syndrome
08/2005
1Hypercholesterolemia
02/2004

Drug/Important Bio-Agent (IBA)

11Glycine (Aminoacetic Acid)FDA LinkGeneric
03/2022 - 01/2011
10Glutathione (Reduced Glutathione)IBA
03/2022 - 01/2011
7Acetylcysteine (Siran)FDA LinkGeneric
03/2022 - 09/2020
7Glucose (Dextrose)FDA LinkGeneric
01/2021 - 12/2006
7LipidsIBA
01/2014 - 07/2006
5Cysteine (L-Cysteine)FDA Link
12/2021 - 01/2011
5AntioxidantsIBA
12/2021 - 01/2011
4Insulin (Novolin)FDA Link
01/2021 - 06/2011
4Fatty Acids (Saturated Fatty Acids)IBA
01/2014 - 08/2010
4Triglycerides (Triacylglycerol)IBA
07/2011 - 06/2005
4HDL CholesterolIBA
07/2011 - 08/2002
3LeptinIBA
10/2012 - 12/2006
3Niacin (Nicotinic Acid)FDA LinkGeneric
07/2011 - 12/2006
2Oxidants (Oxidizing Agents)IBA
12/2021 - 01/2011
2Amino AcidsFDA Link
12/2021 - 01/2011
2Muscle Proteins (Muscle Protein)IBA
01/2021 - 09/2020
2IsotopesIBA
01/2014 - 06/2011
2Fenofibrate (CiL)FDA LinkGeneric
07/2011 - 12/2006
2AdiponectinIBA
07/2011 - 12/2006
2very low density lipoprotein triglycerideIBA
06/2011 - 12/2006
2Growth Hormone (Somatotropin)IBA
08/2010 - 07/2006
1Thiobarbituric Acid Reactive SubstancesIBA
12/2021
1F2-Isoprostanes (F2 Isoprostanes)IBA
12/2021
1Biomarkers (Surrogate Marker)IBA
01/2021
1Biological ProductsIBA
09/2020
1Proteins (Proteins, Gene)FDA Link
09/2020
1CarbohydratesIBA
01/2014
1Protein Kinases (Protein Kinase)IBA
11/2013
1Adenosine Monophosphate (AMP)IBA
11/2013
1PalmitatesIBA
06/2013
1Nonesterified Fatty Acids (NEFA)IBA
06/2013
1metreleptinIBA
10/2012
1C-Reactive ProteinIBA
07/2011
1Rosiglitazone (Avandia)FDA Link
06/2011
1ThiazolidinedionesIBA
08/2010
1acipimoxIBA
08/2010
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
08/2010
1Fibric Acids (Fibrates)IBA
08/2010
1LDL CholesterolIBA
08/2010
1Lipoproteins (Lipoprotein)IBA
12/2006
1Cholesterol Esters (Cholesteryl Esters)IBA
12/2006
1Carrier Proteins (Binding Protein)IBA
12/2006
1Adenosine Triphosphate (ATP)IBA
12/2006
1oxidized low density lipoproteinIBA
12/2006
1Peptides (Polypeptides)IBA
08/2005
1Pro-Opiomelanocortin (Proopiomelanocortin)IBA
08/2005
1CytokinesIBA
05/2004

Therapy/Procedure

4Therapeutics
10/2012 - 12/2006
3Highly Active Antiretroviral Therapy (HAART)
04/2013 - 02/2004
1Surgical Amputation (Amputations)
02/2022
1Art Therapy
07/2011
1Drug Therapy (Chemotherapy)
08/2010